C3042
Sigma
Corticotropin Releasing Factor human, rat
≥95% (HPLC)
| Synonym: | CRF, CRH |
| Amino Acid Sequence: | Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2 |
| CAS Number: | 86784-80-7 |
| Linear Formula: | C208H344N60O63S2 |
| Molecular Weight: | 4757.45 |
| MDL number: | MFCD00213806 |
Description
| Biochem/physiol Actions | CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress. |
Properties
| assay | ≥95% (HPLC) |
| Gene Information | human ... CRH(1392) |
| storage temp. | −20°C |
Safety
| WGK Germany | 3 |
| RTECS | GM7925000 |
References
| reference | Koob, G.F., and Heinrichs, S.C., A role for corticotropin releasing factor and urocortin in behavioral responses to stressors. Brain Res. 848, 141-152, (1999) |
| Perrin, M.H., and Vale, W.W., Corticotropin releasing factor receptors and their ligand family. Ann. N.Y. Acad. Sci. 885, 312-328, (1999) | |
| Eckart, K., et al., Actions of CRF and its analogs. Curr. Med. Chem. 6, 1035-1053, (1999) |
